Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression

Toward A Tumor-Associated Phenotype Ovarian Cancer Cells Polarize Macrophages

P157: Periostin Recruits Tumor Associated Macrophages in Glioblastoma Multiform

Glioblastoma multiform (GBM) is the most common and lethal type of primary brain tumors with high rates of morbidity and mortality. Treatment options are limited and ineffective in most of the cases. Epidemiological studies have shown a link between inflammation and glioma genesis.  In addition, at the molecular level, pro-inflammatory cytokines released from activated microglia can increa...

Tumor-Associated Macrophages Contribute to Tumor Progression in Ovarian Cancer

Ovarian cancer is the leading cause of death in women with gynecological malignancy and improvements in current treatments are needed. As with many other solid cancers, the ovarian tumor microenvironment is emerging as a key player in tumor progression and a potential therapeutic target. The tumor microenvironment contains several non-malignant cell types that are known to contribute to tumor p...

Infiltration of M2 Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma Correlates with Tumor Malignancy

Tumor-associated macrophages (TAMs) are a major cellular component in the tumor microenvironment of many solid tumors. The functional competence of TAMs varies depending on the type of tumors and their respective microenvironments. The classically activated M1 macrophages exhibit antitumor functions, whereas the alternatively activated M2 macrophages exhibit protumor functions that contribute t...

Cancer Progression Related with Tumor-associated Macrophages

Tumor-associated macrophages are one of the main populations of inflammatory cells in cancers that favor tumor cell growth and survival. Tumor-derived factors such as VEGF-A and CSF-1 recruit the macrophages in tumor micro environment and alter their phenotype in M1 to M2 or tumor-associated macrophages by secretion of several cytokines including IL-4, IL-13 and VEGF-A. In return tumor-associat...